Sayler Park is a neighborhood in Cincinnati, Ohio. The west side neighborhood on the Ohio River is approximately 1 mile (1.6 km) and 2 miles (3.2 km) wide. The population was 2,765 at the 2010 census.
Sayler Park was annexed by the City of Cincinnati in 1911. The neighborhood is known for its F5 tornado in 1974 during the Super Outbreak (one of seven F5 tornadoes during that outbreak) which killed three and demolished many homes.